VPS13C and Mental deterioration: The vacuolar protein sorting 13 C (VPS13C) gene was first identified as a new risk gene for PD in a meta-analysis of genome-wide association studies (GWAS) [230], and later homozygous and compound heterozygous PTC mutations in VPS13C were associated with a distinct form of early-onset parkinsonism characterized by rapid and severe disease progression and early cognitive decline [193].