ATP13A2 and Parkinson disease: Moreover, single heterozygous mutations in PARK2, PINK1, DJ-1 and ATP13A2 are significantly more prevalent in PD or EOPD patients compared to control individuals [4, 75, 80, 133, 154, 170, 199, 238, 322, 330], suggesting these variants increase risk for PD, act as onset modifiers for PD, or contribute to the disease together with other mutations in an oligogenic fashion.