In a patient-derived stem cell model of PD carrying the SNCA p.Ala53Thr mutation, basal and mitochondrial toxin-induced nitrosative/oxidative stress resulted in S-nitrosylation of transcription factor myocyte-specific enhancer factor 2C (MEF2C), thereby inhibiting the transcription of PGC1α [289]. Here, PPARGC1A is linked to Parkinson disease.