Conversely, we found that MYCN amplified neuroblastoma cell lines show a significantly greater in vitro sensitivity to single agent AZD6738 than non-MYCN amplified neuroblastoma cell lines (Fig. 3a-c), and a preliminary dose finding study demonstrated sensitivity to single agent AZD6738 in the Th-MYCN transgenic mouse model of MYCN driven neuroblastoma [76] (Fig. 3d-e). The gene discussed is MYCN; the disease is neuroblastoma.