ERN1 and perinatal asphyxia: In our previous study, we explored the optimal dose of STF083010 (45 μg/pup), a specific inhibitor of IRE1α’s RNAase activity, for treatment in HIE rat model and evaluated STF083010 protective effects by measuring infarct volume and performing neurobehavioral testing at 24 h and 72 h after HI insult [5].