In summary, our findings reveal a novel role of CD11b in LC/NE neurodegeneration through NLRP3 inflammasome-dependent microglial proinflammatory activation and oxidative stress in a two pesticide-induced mouse PD model, providing a novel insight for the immunopathogenesis of LC/NE neuronal damage in PD. The gene discussed is ITGAM; the disease is Parkinson disease.