NPPB and hydrops fetalis: PIONEER-HF further confirmed the necessity of early use of sacubitril/valsartan in HFrEF [24], and the reduction in N-terminal pro-B-type natriuretic peptide (NT-pro BNP) concentration was weakly yet significantly correlated with reverse cardiac remodelling at 12 months [25]; however, sacubitril/valsartan showed no better reduction in central aortic stiffness than enalapril in HFrEF [26].