LIVE, a randomized, double-blinded, placebo-controlled multicentre trial, determined that although the GLP-1 analogue liraglutide did not affect LV systolic function compared with placebo in stable CHF patients with and without T2DM, treatment with liraglutide was associated with an increase in HR and more serious cardiac adverse events [142]. This evidence concerns the gene GCG and type 2 diabetes mellitus.