However, no relevant studies support the hypothesis that eplerenone has a significantly beneficial effect on glucose homeostasis in patients with HFrEF and either glucose intolerance or diabetes [63].Finerenone was well tolerated and induced a 30% or greater decrease in NT-proBNP levels in a similar proportion of patients to eplerenone [64], and finerenone was well tolerated in Japanese patients in ARTS-HF Japan [65]. This evidence concerns the gene NPPB and hydrops fetalis.