The KEGG pathways of the ten hub genes were Ubiquitin mediated proteolysis, Focal adhesion, extracellular matrix (ECM)-receptor interaction, PI3K-AKT signaling pathway, Small cell lung cancer, Amoebiasis, Pathway in cancer, Circadian rhythm, African trypanosomiasis, Hedgehog signaling pathway, and Shigellosis (Additional file 1: Fig. S1B). This evidence concerns the gene AKT1 and cancer.