In the T2D patients, the mean ratio between phosphorylated to total MYPT1 and ERM (MYPT1-P/T and ERM-P/T) in circulating leukocytes, was significantly increased by threefolds (Fig. 1, p < 0.001) and fivefolds (Fig. 2, p < 0.001), respectively, compared to control subjects. The gene discussed is PPP1R12A; the disease is type 2 diabetes mellitus.