Overexpression of ADRM1 mRNA and /or RPN13 was reported in many types of malignancy, including multiple myeloma, diffuse large B-cell lymphoma, gastric cancer, ovarian cancer, and intrahepatic cholangiocarcinoma and high expression of RPN13 correlated with poor prognosis [11]. The gene discussed is ADRM1; the disease is AL amyloidosis.