PIK3CA and Familial prostate cancer: We found the ALDH1A3 signature had significant positive correlation with ERG signature and prostate cancer luminal signature, respectively (Enrichment score: 0.77, 0.5; Both p value: < 0.01) (Fig. 2a, b), and it had negative correlation with lymph nodes and PI3K-AKT-mTOR signaling pathway, meaning that ALDH1A3low group might be associated with lymph nodes metastasis and PI3K-AKT-mTOR signaling activation (Fig. 2c, d).