Case fatality rate of scrub typhus is 6% for untreated and 1.4% for treated cases [1]., [4] Therefore, a high degree of clinical suspicion is required for the diagnosis of scrub typhus which can be confirmed by a rapid diagnostic test or polymerase chain reaction (PCR); Indirect immunofluorescence assay (IFA) being the gold standard test—a four-fold rise in IgM antibody titer is usually diagnostic of infection [5]. The gene discussed is CD40LG; the disease is scrub typhus.