After adjustment for other potential confounders including BMI, admission heart rate, admission systolic pressure, cholesterol, low-density lipoprotein, hs-CRP, and a history of hypertension, diabetes mellitus, hyperlipidemia, or smoking, both SSII and ESR were still independent powerful predictors for the incidence of MACE in patients with STEMI and multivessel disease (ESR, HR = 1.022, 95% CI = 1.012–1.033, p < 0.001; and SSII, HR = 1.033, 95% CI = 1.017–1.049, p < 0.001). This evidence concerns the gene CRP and Hypertension.