Using different human colon cancer cell lines treated with hydrogen peroxide to induce apoptosis and NSAIDs and different concentrations of the PPARβ/δ agonist GW0742, the authors did not observe a decrease of early (evidenced by annexin V labeling) or late (analyzed by PARP cleavage) apoptosis upon PPARβ/δ activation [51]. This evidence concerns the gene PPARD and colonic neoplasm.