CDK4 and gastric cancer: Tob1 decreased the phosphorylation of Akt and glycogen synthase kinase-3β (GSK3β), resulting in reduced expression and the transcriptional activity of β-catenin, which in turn decreased the expression of PPARβ/δ, cyclin D1, cyclin-dependent kinase-4 (CDK4) and urokinase plasminogen activator receptor (uPAR) in gastric cancer cells [127].