In contrast to the reports mentioned above, another study confirmed APC/beta-catenin-dependent expression of Cyclin D1, while expression of PPARβ/δ was not different in colon or intestinal polyps from wild-type or Apc(min) heterozygous mice or in human colon cancer cell lines with mutations in APC or beta-catenin [122]. The gene discussed is APC; the disease is malignant colon neoplasm.