As HNPCC patients are more susceptible to develop colorectal cancer (CRC), the authors hypothesized that the overproduction of PGI2 from the stroma of HNPCC patients prevents apoptosis of neoplastic lesions through activation of PPARβ/δ and therefore facilitates progression into a malignant state of CRC [110]. This evidence concerns the gene PPARD and hereditary nonpolyposis colon cancer.