Lack of oxygen results in hypoxia in the tissue, which results in stabilization of hypoxia- induced factors (Hif) [151,152,153] and subsequent activation/inhibition of downstream target genes, e.g., VEGF [154], erythropoietin [155], WT1 [156], PPARα [157], glucose transporters (Glut-1 and Glut-3) and many other target genes involved in cancer metabolism (for a recent review see [158]). The gene discussed is SLC2A1; the disease is cancer.