PPARD and breast cancer: PPARβ/δ mediated inhibition of breast cancer cell migration and invasion was proposed to be regulated via thrombospondin-1 (TSP-1) and its degrading protease, a disintegrin and metalloprotease domains with thrombospondin motifs 1 (ADAMTS1), as knockdown of ADAMTS1 reduced the effects of PPARβ/δ activation; and ADAMTS1 promoter activity was increased by GW501516 [130].