TP53 and B-cell chronic lymphocytic leukemia: In particular, the TP53 status (no abnormalities vs. del [17p] or TP53 mutation or both) and the IGHV mutational status (mutated vs. unmutated) are considered major prognostic markers in CLL, and have been included in a prognostic index, the International Prognostic Index for Chronic Lymphocytic Leukemia (CLL-IPI), together with clinical features and serum markers [75].