MYC and B-cell neoplasm: Burkitt lymphoma (BL) which is a mature B cell neoplasm can present in the following two clinical entities: the endemic (African) form is caused by Epstein–Barr virus (EBV) infection with a specific translocation t(8;14)(q24;q32) involving MYC/c-Myc and the heavy chain immunoglobulin genes; and a sporadic form accounting for 1%–2% of adult lymphomas and for about 40% of pediatric diseases [1,2].