We did not notice any statistical differences in interactions in log-linear analysis in relation to frequency of VDR rs1544410, VDR rs2228570, VDR rs7975232 genotypes between smokers and non-smokers and pathologies in the oral cavity (mouth dryness, periodontitis, dry socket, redness of oral cavity mucosa, leukoplakia). This evidence concerns the gene VDR and Oral leukoplakia.