The autocrine motility factor receptor, AMFR, encodes a glycosylated transmembrane receptor that is also an E3 ubiquitin ligase, knockdown of which in the acute monocytic leukemia cell line, THP-1, induces cell cycle arrest and apoptosis, indicating a critical role for AMFR in cell proliferation [19]. The gene discussed is AMFR; the disease is acute monocytic leukemia.