Gc-globulin serum levels were significantly lower in patients suffering from ALF due to metabolic disorder (42.54 ± 36.79 mg/L), infection (82.10 ± 14.11 mg/L) or unknown cause (87.89 ± 40.52 mg/L) compared to autoimmune (290.45 ± 200.40 mg/L) and toxic ALF (228.94 ± 234.02 mg/L) (p = 0.0102). Here, GC is linked to metabolic disease.