Extended prothrombin time (>50 s), low levels of plasma coagulation factors V and VII, cerebral oedema, severity of encephalopathy, sudden reduction in transaminases or liver size, high levels of α-fetoprotein (AFP), electrolyte disturbances, MELD and PELD scores and King’s College criteria were studied as predictive factors for the evolution of ALF in children [4,5,6,9,10,11,23,24,25,26,27]. This evidence concerns the gene F2 and brain edema.