Studies conducted in tumor-bearing immunocompetent mice have recently demonstrated that a glucose-depleted TME limits aerobic glycolysis in tumor-infiltrating T cells, which suppresses anticancer effector functions; however, inducing the expression of the PEP carboxykinase 1 (PCK1) in tumor- infiltrating CD4+ T cells is sufficient to restore PEP levels and promotes T cell signaling through the TCR [45]. This evidence concerns the gene CD4 and neoplasm.