Consistently, the blockade of the PGE2-producing enzyme, microsomal PGE2 synthase 1 (mPGES1), and cyclooxygenase-2 (COX-2) promoted a reversion of M2-M1 polarization of TAMs in an Apcmin/+ colon cancer model [136], while COX-2 inhibition resulted in reduced PD-L1 expression in bladder cancer [90]. This evidence concerns the gene PTGS2 and urinary bladder carcinoma.