However, TLR7 deficiency results in attenuated production of type I IFN by pDCs [69], reduced IL-1β secretion from bone marrow-derived DCs [71], and impaired activation and production of IFN-γ by lung natural killer cells (NK cells) during infection [72], suggesting that TLR7 is responsible for efficient innate immune responses against the influenza virus. The gene discussed is TLR7; the disease is infection.