Unfortunately, a limitation of our study is that we have no data about the (renal) GDF15 production rates and or the contribution of the kidney to the clearance of GDF15 and, of course, there are several factors such as infections or cardiovascular disease that could affect graft function and thus may nullify the feasibility of GDF15 in LD to predict graft function in recipients more sensitively. This evidence concerns the gene GDF15 and cardiovascular disorder.