VEGFA and neoplasm: Moreover, tumor-derived growth factors such as vascular endothelial growth factor (VEGF) stimulate rapid angiogenesis without sufficient control from angiogenesis inhibitors, which leads to the formation of tortuous vessels with loose EC junctions [8], little or no perivascular cell coverage [9], and an overall leaky nature, further contributing to the high interstitial fluid pressure observed in tumors [10,11].