Bastian et al. 30described the mechanism of melanoma initiation as a result of bi‐allelic loss of CDKN2A, and consequently p16INK4A, via activation of BRN2, a transcription factor downstream of CDKN2A. Further investigations will be necessary to fully elucidate all aspects of invasion, thereby possibly uncovering new prognostic markers. The gene discussed is POU3F2; the disease is melanoma.