BRCA1/2 sequence variants (including deleterious mutations, variants of unknown significance, and deleterious germline variations) were also highly prevalent, at frequencies of 5.6% for BRCA1 and 7.2% for BRCA2. These alterations have been consistently associated with breast cancer in prior reports [14,15,17,24,45,48]. Here, BRCA1 is linked to breast cancer.