SOAT1 and metastatic neoplasm: Recent work in small cohorts of ~100–1000 metastatic tumors suggests that the majority of alterations are shared between primary tumors and metastases, and that JAK/STAT and SWI/SNF pathways are dysregulated at higher rates in metastatic disease; these studies have also implicated genes involved in DNA damage repair, the MAPK pathway, and epigenetic regulators [28–32].