NOTCH1 and lung carcinoma: KRAS is the most common driver mutation in lung cancer, and is highly co-occurrent with KEAP1 and STK11 mutations [58,59], NOTCH1 has a putative role in skin cancer [60], loss of PTEN is the most common genomic alteration in glioblastoma [61], and DNMT3A has been associated with leukemia and myelodysplasia [62,63].