For category 1, we identified a significant correlation of CCNE2-FOXM1 (10 cell line lineages, 17 patient cancer types) in cell cycle CTNNB1-SERPINE1 (eight cell line lineages, 17 patient cancer types) in EMT, and RB1-RPS6 (eight cell line lineages, 20 patient cancer types) in TSC/mTOR pathways. The gene discussed is RB1; the disease is cancer.