In osteoblasts, it has been shown that down‐regulation of STAT‐1 or STAT‐3 reduces the expression of CCL‐234 and in a lung cancer cell line, STAT‐1 was linked to IL‐8 expression,35 whereas TNF‐α synthesis is regulated via NFκB signalling. The gene discussed is NFKB1; the disease is lung carcinoma.