INS and Insulin resistance: During pregnancy, HOMA and Matsuda indices did not differ between NZO and NMRI mice (NZO vs. NMRI: HOMA: 3.86 ± 0.99 vs. 2.63 ± 0.37, ns; Matsuda: 4.36 ± 0.63 vs. 6.03 ± 0.50, ns), since insulin resistance decreased and insulin sensitivity increased significantly in NZO.