Preconceptionally, HOMA and Matsuda indices differed significantly between the two strains, implying increased insulin resistance (NZO vs. NMRI: 12.34 ± 3.09 vs. 1.98 ± 0.44, p = .0001) and decreased insulin sensitivity of the NZO (NZO vs. NMRI: 1.85 ± 0.25 vs. 10.03 ± 1.84, p = <.0001). The gene discussed is INS; the disease is Insulin resistance.