Results showed that rs137853294 polymorphism (OR, 2.272; 95% CI, 0.088–0.084; P=0.024) and rs121913300 polymorphism of RB1 (OR, 0.264; 95% CI, 0.082–0.0851; P=0.026) showed positive association with tumor grades. Here, RB1 is linked to neoplasm.