For CCND1 gene, rs614367 and rs498136 also showed positive association with tumor grades (OR, 4.197; 95% CI, 0.054–0.771; P=0.014 and OR, 2.137; 95% CI, 0.258–5.007; P=0.03), as shown in Table 5. The gene discussed is CCND1; the disease is neoplasm.