In addition, previous studies reported that genetic anomaly of TRPV4 causes genetic skeletal disorders, such as metatropic dysplasia, brachyolmia, spondylo-epimetaphyseal dysplasia, and parastremmatic dysplasia (Nilius and Owsianik, 2010; Andreucci et al., 2011; Nishimura et al., 2010; Lamandé et al., 2011; Loukin et al., 2011; Graversen et al., 2018). The gene discussed is TRPV4; the disease is metatropic dysplasia.