In agreement with a previous study that reported the cytokine TNFα to be a direct target of miR-130a in cervical cancer cell lines (Zhang J. et al., 2014), the authors observed a correlation between low levels of miR-130a and high plasma levels of TNFα in head and neck cancer patients, confirming the key role of inflammation in the onset of cancer-associated cachexia. Here, TNF is linked to cancer.