Supporting the key role of inflammation in cancer-related cachexia occurrence, recently Penafuerte et al. (2016) reported an increase in neutrophil-derived proteases (NDPs), angiotensin II (Ang II), transforming growth factor beta 1 (TGFβ1) and C-reactive protein (CRP) plasma levels in cachectic and pre-cachectic cancer patients. This evidence concerns the gene TGFB1 and cancer.