AKT1 and glioblastoma: Another study reported that ZD6474, a small-molecule inhibitor that suppresses the activities of epidermal growth factor receptor, vascular endothelial growth factor receptor, and tyrosine kinases receptor, can activate autophagy depending on attenuation of the PI3K/AKT/mTOR signaling pathway to protect glioblastoma cells (Shen et al., 2013).