In addition, mTORC1 and mTORC2 affect oncogenic pathways, such as phosphatidylinositol-3-OH kinase (PI3K)-PKB/Akt pathway, and thus their signaling is frequently activated in cancer, for example in glioblastoma and follicular lymphoma (Kim and Guan, 2019). This evidence concerns the gene AKT1 and glioblastoma.