The observation showing no differences in the survival rates after infection of two different cell types with T. cruzi msh6-/-, whereas a clear difference was observed when macrophages were infected with msh2 mutants compared to WT parasites (Grazielle-Silva et al., 2015), also points toward a distinct role between these two MMR components in the oxidative stress response of T. cruzi. Here, MSH2 is linked to infection.