The protein kinase named General Control Non-repressible 2 (GCN2), which is activated in the presence of uncharged tRNAs and nutritional stress (Dever and Hinnebusch, 2005); the Heme Regulated Inhibitor (HRI) kinase, which acts in response to low level of intracellular heme (Chen and London, 1995); the RNA-dependent protein kinase (PKR), which is activated in response to viral infections (Garcia et al., 2007); and PKR-like endoplasmic reticulum kinase (PERK), activated in response to elevated levels of misfolded proteins (Ron and Harding, 2012). This evidence concerns the gene EIF2AK2 and viral infectious disease.