We found that addition of rhIL-6 to CM from ATF3-overexpressing HDFs reversed the inhibitory effect of the CM on proliferation of melanoma cells (Figures 5A,B) and restored the colony growth of both UACC62 (Figure 5C) and Mel-JuSo (Supplementary Figure 3A) cells to control levels. The gene discussed is ATF3; the disease is melanoma.