Among them, CXCL10 gene has been reported to promote cell growth, metastasis and decrease cell apoptosis in chronic myeloid leukemia (31); The high C5AR1 expression is related to shorter overall survival and increased bone metastasis in lung tumors (32); FPR1 gene plays a key role in the mechanism of cellular drug resistance in acute lymphoblastic leukemia (33); LHCGR gene expression is correlated with adrenocortical tumorigenesis (34). This evidence concerns the gene LHCGR and chronic myelogenous leukemia, BCR-ABL1 positive.