AQP1 and cyclic hematopoiesis: In order to further analyze the association between AQP1 methylation and clinical features in elderly CN-AML, we compared the clinical and laboratory features between AQP1 hypermethylated and AQP1 hypomethylated groups using 8.667 as the median AQP1 methylated value (Figure S3, 39 elderly CN-AML with DNA methylation data, TCGA).