AQP1 hypomethylation group had longer OS than AQP1 hypermethylation group (P = 0.033, Figure 2C, 39 elderly CN-AML with DNA methylation data, TCGA), and AQP1 hypomethylation and high expression was further verified to have prognostic significance (P = 0.039, Figure 2D, 29 elderly CN-AML with DNA methylation data and RNA sequencing, TCGA). Here, AQP1 is linked to acute myeloid leukemia.