Those animals with a tumor mass lower than the average of bintrafusp alfa-treated animals were noted as “Responders,” whereas those animals with a tumor mass higher than the average were indicated as “Non-responders.” As shown in Figures 7C,D, the percentage of PD-1 expression in peripheral and tumor-infiltrating CD8+ T cells, respectively, was significantly lower in responders to bintrafusp alfa when compared with non-responders. Here, PDCD1 is linked to neoplasm.