Second, it has been shown to have the additive effect of counteracting excessive AKT phosphorylation caused by mTOR-inhibitors in experimental models of Ewing sarcoma and rhabdomyosarcoma (59) Hence, there is a rationale for treatment with IGF-1 receptor inhibitors both as standalone treatment and in combination with mTOR inhibitors (60). The gene discussed is MTOR; the disease is Ewing sarcoma.