Among existing reports, one patient showed variants of unknown clinical significance in ARID1A and RUNX1 genes (19) Another study detected no mutations in a panel of 29 genes (including MET, ALK and KIT) evaluated in 24 cases of DSRCT (20) and in a large study of sarcomas analyzed by next generation or Sanger sequencing which included 9 DSRCT samples, few mutations were seen (21). This evidence concerns the gene RUNX1 and desmoplastic small round cell tumor.