In one study, WES analyses of 42 CTCL cases, including 25 SS and 8 MF cases, showed highly prevalent chromosomal deletions involving the TP53, RB1, PTEN, DNMT3A, and CDKN1B tumor suppressors, which broadly implicates epigenetic regulation and signaling (5). The gene discussed is TP53; the disease is synovial sarcoma.