In one study, WES analyses of 42 CTCL cases, including 25 SS and 8 MF cases, showed highly prevalent chromosomal deletions involving the TP53, RB1, PTEN, DNMT3A, and CDKN1B tumor suppressors, which broadly implicates epigenetic regulation and signaling (5). This evidence concerns the gene PTEN and synovial sarcoma.