Meanwhile, methylation of several non-histone proteins participated in tumor-associated signaling pathways, including p53 (14, 15), RB1 (16, 17), NF-κB (18, 19), STAT3 (20), etc. EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3 (20). This evidence concerns the gene EZH2 and neoplasm.