In further analysis, the results showed that high risk score had a worse prognosis in LGG with IDH-mutant subgroup in both cohorts (P = 0.01 and 0.0026, Figure 4J, Figure S4J), but no significant difference in GBM IDH-mutant subgroup (P > 0.05, Figure 4L, Figure S4L). The gene discussed is IDH2; the disease is glioblastoma.