Previous studies have shown, VEGF level in serum of stage III breast cancer patients was higher than in the stage I or II breast cancer and healthy people.15,16 Our results is in agreement with the previous studies and indicate the mean MVD of VEGF is increased in the early stage and risen steadily in the intermediate stage, soared significantly in the advanced stage and then reached to the end stage with a gradually rise. Here, VEGFA is linked to breast cancer.