Quantitatively speaking, in early stages of tumor growth, the average relative expression level of Hif1α, VEGFR1 and VEGFR2 were 3.48- (P < 0.05), 0.75- (P < 0.05) and 7.6-fold (P < 0.01), respectively, in comparison to healthy controls. This evidence concerns the gene HIF1A and neoplasm.