HIF1A and neoplasm: In the experiments with TNBC patients, the results showed that HIF1α in TNBC patients are more expressed than non-TNBC and there was a considerable correlation between Hif1α expression, tumor size and pathologic stages.28 In syngeneic mouse models, HIF1α also promotes the growth, invasion, and metastasis of TNBC cells.29 In our experiment, the expression of HIF1α is initiated in the early stage when the tumor volume is less than 100 mm3 and as the tumor grew, the expression of HIF1 is increased (P < 0.05) and reached to the highest level in the end stage.