TP53 and neuroblastoma: CuO-NPs induced genotoxic responses via the p53 and p38 pathways in A549 lung cells.11,30,38 CuO-NPs significantly induced DNA damage at 12.5 μg/mL in mouse N2A neuroblastoma cells, with no decrease in cell viability.28 CuO-NPs induced both cell death and DNA damage in human A549 and BEAS-2B lung epithelial cells via disruption of cell membrane integrity.40 Akhtar et al observed the tail moment was 27% (5.4 fold compared to NC) at 15 μg/mL of CuO-NPs (P < 0.05).41