The tumor cells are positive for Creatine kinase (CK) and desmin [8]. The tumor often stains positive for neuroendocrine markers such as synaptophysin, CD56, and chromogranin. There have been five reported cases of pancreatic PNETs with local recurrence, three cases with lung metastasis and one case with bone metastasis [27-30]. This evidence concerns the gene SYP and neoplasm.