The MCD diet in mice significantly decreased Apo B gene expression compared with the control group (0.87±0.03 vs 1, P<0.05) while in the NASH+allantoin group it significantly increased compared with the NASH group (2,229.8±5.87 vs 0.87±0.03, P<0.001). This evidence concerns the gene APOB and metabolic dysfunction-associated steatohepatitis.