Since ER stress promotes NASH via changes in lipid metabolism-related gene expression (7), ER stress inducer genes (GRP78 and ATF6) and expression of lipid metabolism-related genes (SREBP1c, PPARα, FAS, Apo B, and ACAT1) and effects of allantoin on them were evaluated. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.