This study showed that GRP78 gene expression, as ER stress chaperon, significantly increased in the NASH group compared with the control group (1.55±0.032 vs 1, P<0.01) while it significantly decreased in the NASH+allantoin group compared with the NASH group (0.123±0.013 vs 1.55±0.032, P<0.001) (Figure 3A). The gene discussed is HSPA5; the disease is metabolic dysfunction-associated steatohepatitis.