SNCA and Parkinson disease: In experimental models of PD, the cytotoxic microglia (M1) have been evidenced during the progress of DN degeneration in SNpc as a consequence of ROS increase, Lewy bodies (LB) formation, and cell death; stimuli as aggregated alpha-synuclein in Lewy bodies may activate M1-microglia and favor the release of pro-inflammatory responses.