To further delineate the cellular and molecular mechanisms underlying the regulation of PAH, a proteome-wide screening was performed using isobaric tags for relative and absolute quantitation-coupled 2D LC-MS/MS (liquid chromatography mass spectrometry) approach to identify the changes in Myadm-mediated gene expression in response to MCT-induced PAH. This evidence concerns the gene MYADM and pulmonary arterial hypertension.