IL-8 activates FoxC1 expression via the PI3K/AKT pathway and via hypoxia-inducible factor 1 alpha, and FoxC1 expression induces CXCR1 and CCL2 transactivation and promotes inflammation in hepatocellular carcinoma (HCC) and the migration and invasion of HCC cells 31. This evidence concerns the gene HIF1A and hepatocellular carcinoma.