TP53 and hepatocellular carcinoma: There are lots of reports on the role of TP53 genetic alterations in HCC: The R273L mutation is a dominant-negative mutation that contains a point mutation in the DNA-binding domain and is commonly found in various types of cancers 29; Inactivating mutations of TP53 were one of the main potential drivers and enriched in HBV-related HCC 30.