DLL4 and neoplasm: The effect of DLL4 levels in the tumor microenvironment on uptake and therapy response was independent of the NP configuration in terms of shape and sizes for the two variants tested in this manuscript: (1) PEGylated Au nanorods with dimensions 10 by 40 nm, hydrodynamic radius: 80 nm, charge -9 mV, and (2) PEGylated TNPs with Gd2O3 coating on Au nanorods resulting in oblong spheroid shape of size 75 nm, hydrodynamic radius 235 nm, +7.6 mV.