Analysis of tumor growth inhibition (TGI) by bioluminescent imaging verified similar TGI was observed in SSIL2Rγ- rats bearing 1806rluc+ tumors and treated by anti-DLL4-conjugated TNPs as compared to SSIL2Rγ- rats treated with control IgG-TNPs (Figure 6E and Figure S6). The gene discussed is DLL4; the disease is neoplasm.