Tumor regression was similar in SS.BN3IL2Rγ- rats whether treated by anti-DLL4-conjugated TNPs or IgG-conjugated TNPs followed by PTT (Figure 6D), however, strong differences in TGI were observed in SSIL2Rγ- (DLL4-high strain) rats when treated by DLL4-conjugated TNPs vs control IgG-TNPs. The gene discussed is DLL4; the disease is neoplasm.