DLL4 and neoplasm: Vascular differences determine NPs distribution in tumor tissues. Since the TNPs uptake was lower in SS.BN3IL2Rγ- compared with SSIL2Rγ- (Figure 2A-B), yet paradoxically TGI was significantly greater in SS.BN3IL2Rγ- (Figure 3A-F) without an appreciable difference in ablative temperatures (Figure 3G-H), we hypothesized that the inherited TME vascular heterogeneity associated with DLL4 expression likely altered distribution of TNPs within the tumors.