NFKB1 and metabolic dysfunction-associated steatohepatitis: Thus, understanding the function of PTPROt in liver macrophages during NASH progression and the relationship between PTPROt, NF-κB, ROS, mitophagy, and the inflammasome-proinflammatory cytokine axis may attribute to understanding the mechanism of NASH pathogenesis and allow for an exploration into potential preventative and therapeutic strategies for NASH.