Thus, understanding the function of PTPROt in liver macrophages during NASH progression and the relationship between PTPROt, NF-κB, ROS, mitophagy, and the inflammasome-proinflammatory cytokine axis may attribute to understanding the mechanism of NASH pathogenesis and allow for an exploration into potential preventative and therapeutic strategies for NASH. Here, PTPRO is linked to metabolic dysfunction-associated steatohepatitis.