In our study we also found that Mzb-induced a significant downregulation of the key regulator of cell metabolism PGC-1α, which has been shown to be upregulated in metastatic breast cancer cells and to promote breast cancer metastasis by stimulating OXPHOS, increasing cell motility and invasive properties without impacting the expression of EMT-related genes 28, suggesting that Mzb catalyzed suppression of PGC-1α levels is not mutually exclusive to suppression of EMT markers. This evidence concerns the gene PPARGC1A and breast carcinoma.