FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) and is associated with two leukemogenic fusion genes, the FIP1L1-retinoic acid receptor alpha (RARA) and the FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA), thus contributing to the pathogenesis of distinct types of leukemia 47, 48. This evidence concerns the gene RARA and leukemia.